I suffered for several years with extreme bowel incontinence, not knowing when or how long I had to get to the bathroom. Three different doctors tried different medicines some would work for a short time ,then the diarrhea would overpower and I was right back at square one . Dr. Winston implanted a stimulator in my hip. When that also didn't work completely, he decided to look through my meds( I take a lot of them) he noticed I was taking 4 metformin 500mg twice daily for diabetis . He said stop those and have my primary Dr. prescribe something else. Within 3 days my movements returned to what they were years ago. I no longer have to plan ahead or sit around the house not knowing what kind of day I will have. Anyone with similar symptoms and taking metformin should ask their Dr. about it. A special thanks to Dr. John H. Winston 111 for giving me my life back. Thanks Dr. John ,You are my hero. I am 75 yrs. old .